Diphenyl diselenide a janus faced molecule examples

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Introduction of Tellurium into Organic Substrates There are many synthetic transformations mediated by tellurium reagents. The hydrotelluration methodology has been successfully applied to activated olefins, constituting a useful method to prepare functionalized alkyltellurides, as illustrated in Scheme 6. Figures and Tables. Figures, Tables, and Topics from this paper. As an alternative to the use of organolithiums, milder non functionalized organometallics 1 can be generated from a commercially available organolithium and an inorganic salt, and then reacted with 2a precursor of the structurally more complex organometallic 3which is more selective than the corresponding organolithium Scheme 2. In one study the electrophilic substitution was performed in a solventless process 11 and in another one the hygroscopic tellurium tetrachloride was prepared and reacted in situ with the aromatic compound. On the other hand, organotellurides in hexane under an oxygen atmosphere at room temperature under sunlight irradiation were rapidly transformed into the corresponding aldehydes.

  • Cristina W Nogueira Citações do Google Acadêmico
  • Diphenyl diselenide a janusfaced molecule
  • Reactive organometallics from organotellurides application in organic synthesis

  • images diphenyl diselenide a janus faced molecule examples

    Diphenyl Diselenide a Janus-Faced Molecule Pharmacological effects of diphenyl diselenide on different experimental models For example, this compound has been shown to prevent oxidative stress at the cardiovascular level in. REVIEW.

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    Diphenyl diselenide a janus-faced molecule. Cristina W. Nogueira; João B.T. Rocha. Departamento de Química, Centro de Ciências. enzyme mimetics Diphenyl diselenide a janus-faced molecule · author index.

    In Scheme 4 is given a recent example of this transformation.9 In the phenyl-​vinyl telluride (4) there are two sites for exchange, since two.
    Marino, J.

    images diphenyl diselenide a janus faced molecule examples

    Keywords: organotellurides, tellurides, organometallics, natural products. This compound was converted into montiporic acid B after four additional steps Scheme SodaE. The last controversial concern involving the organic derivatives of tellurium is their toxicity.

    Cristina W Nogueira Citações do Google Acadêmico

    The generalized use of vinylic tellurides as source of vinyllithiums and other vinyl organometallics was only possible with the advent of the aliphatic derivatives of tellurium, which before the s were considered by the chemists as too unstable to be handled.

    Since we developed methods to prepare alkyl derivatives of tellurium, and showed that they are stable enough to be handled without need for special experimental conditions, 22,23 this branch of chemistry experienced a considerable evolution.

    images diphenyl diselenide a janus faced molecule examples
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    This toxin is responsible for seafood intoxications, paralytic shellfish poisoning and diarrhetic shellfish poisoning, also called gastroenteritis.

    Direct transformation of organotellurides into organosodium, calcium, magnesium, aluminum, zinc, copper and manganese compounds Organotellurides can be transformed into the title organometallics by direct reaction of the telluride with a commercially available or easily prepared organo-derivative of the mentioned metals.

    Silva, M.

    Diphenyl diselenide a janusfaced molecule

    This last transformation equation 2 was subject of two recent improvements. In Scheme 5 is shown the general procedure for this transformation. Mirzayans, P. Nogueira, C.

    [], and there is a report [] that diphenyl diselenide produces a significant as “Janus-faced” molecules, since the interaction of diphenyl diselenide with thiols can One illustrative example is provided by work carried out in this author's.

    This study investigates the efficacy of diphenyl diselenide [(PhSe) 2] in attenuating For example, ebselen and (PhSe) 2 have been shown to exert Rocha, “Diphenyl diselenide a janus-faced molecule,” Journal of the. For example, diphenyl diselenide (6, R = Ph), and [PubMed]; Nogueira, C.W.; Rocha, J.T.B. Diphenyl diselenide a janus-faced molecule.
    When dialkyltellurides were submitted to the exchange reaction, depending on the nature of the alkyl groups linked to tellurium, s -butyllithium or t -butyllithium were required to successfully perform the exchange reaction.

    Interaction of tellurium tetrachloride with alkynes and aromatics.

    Nogueira, C. Kambe, N. Glutathione derivative and medicine containing the same as active ingredient. Alkali tellurides and alkali ditellurides can be generated by a number of methods, and react in situ with alkylating agents to give the corresponding dialkyltellurides and dialkylditellurides. Most organic compounds of tellurium are not bad smelling at all and some of them even present pleasant smell.

    images diphenyl diselenide a janus faced molecule examples
    Diphenyl diselenide a janus faced molecule examples
    Synthesis of a selenocysteine-containing peptide by native chemical ligation.

    The most important feature of this methodology is that it occurs in an anti fashion, leading to the Z olefin exclusively. We can attribute this attitude to negative comments made in the early literature, when the organic chemistry of tellurium compounds was still in its infancy and little was known about it. Vinylic acetates, tosilates, triflates and phosphonates react with metal tellurolates to give the corresponding vinylic tellurides of the Z configuration irrespective of the configuration of the starting material Scheme 7.

    Tucci, F.

    Reactive organometallics from organotellurides application in organic synthesis

    Some toxicological studies were published 6 and some biological activities of organic and inorganic compounds of tellurium were reported.

    Keywords: selenium; diphenyl diselenide; ebselen; oxidative stress; X-ray absorption .

    Spectra of the samples were recorded in fluorescence mode on [40] C.W. Nogueira, J. Rocha, Diphenyl diselenide a janus-faced molecule, J. Braz. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of Diphenyl diselenide a janus-faced molecule. Molecules; Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: A Diphenyl diselenide a janus-faced molecule.
    Princival; Alcindo A.

    Conclusions Many of the transformations involving a tellurium reagent listed in this account are highly selective and would be difficult to perform using other protocols. William A. Diene methyl ester 41 is a component of the flavor principles of ripe Bartlett pears.

    Petragnani, N.

    images diphenyl diselenide a janus faced molecule examples
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    The aim of this manuscript is to briefly review the most important methods to introduce tellurium into organic substrates and to show the transformation of the resulting organotellurides into reactive organometallics.

    The preparation of Z -organometallics by the classical methods is not a trivial process, 15 contrary to the straightforward way to access such species employing tellurium methodologies. Services on Demand Journal.

    images diphenyl diselenide a janus faced molecule examples

    In he started his graduate studies under the supervision of Prof. A recent paper 5 reports that an organotelluride dissolved in hexane was refluxed for 3 h in the presence of air in the dark with no perceptible decomposition. Only a few classes of organoelemental compounds Figure 1 fulfill the necessary requirements to be replaced by a metal. There are many synthetic transformations mediated by tellurium reagents.